Clinical Case Library
Documented outcomes from scalp clinics and dermatology practices across Asia — demonstrating the clinical effectiveness of Ossome® PRO EXO regenerative therapies across a range of scalp conditions.
Male AGA (Midfrontal Thinning) — PRO EXO Gen Men via Microneedling
Before
After
Key Outcomes
| Measure | Baseline | Post-Treatment |
|---|---|---|
| Norwood–Hamilton | Stage II–III | Stage II |
| Savin Density | Grade 4 | Grade 3 |
| Clinical Finding | Scalp visible; widened thinning zone | Improved density; shedding reduced |
Background
Androgenetic alopecia affects up to 50% of males by age 50, characterised by DHT-driven follicular miniaturisation. Midfrontal thinning is a hallmark of early Norwood–Hamilton staging, often presenting in men as young as their mid-twenties. Exosome-based therapies represent an emerging, well-tolerated alternative to minoxidil and finasteride.
Patient Profile
28-year-old male, 2-year history of progressive midfrontal thinning. Norwood–Hamilton Stage II–III. Sought a non-pharmacological intervention.
Protocol
- Baseline photography and density grading performed
- PRO EXO Gen Men vial prepared per protocol
- Microneedling applied to midfrontal zone to create transdermal channels
- PRO EXO Gen Men applied directly and massaged until absorbed
- Daily homecare: Ossome® Minox Shampoo and Scalp Serum
- Biweekly sessions — 7 total over 3.5 months
Conclusion
PRO EXO Gen Men delivered via microneedling achieved meaningful clinical improvement in midfrontal AGA within 3.5 months, supporting exosome-based regenerative biologics as a safe and patient-acceptable approach for early-stage AGA.
Pre-Hair Transplant Scalp Optimisation — PRO EXO Epi New
Before
After
Key Outcomes
| Measure | Baseline | Post-Treatment |
|---|---|---|
| Clinical Symptoms | Pruritus, flaking, discomfort | Marked reduction; improved comfort |
| Scalp Condition | Erythema, adherent scaling | Clearer scalp; scaling resolved |
| Transplant Suitability | Contraindicated | Suitable — transplant proceeded |
Background
Active seborrhoeic dermatitis poses significant risk in pre-transplant patients: scalp inflammation can compromise graft survival and impair post-operative healing. Exosome-based topical therapies with anti-inflammatory activity offer a targeted, non-steroidal approach to achieving rapid pre-operative scalp normalisation.
Patient Profile
Patient with recurrent seborrhoeic dermatitis — active pruritus, erythema, and adherent scaling — with hair transplant scheduled in 2 weeks. Active inflammation would have contraindicated immediate surgery.
Protocol
- Baseline photography documenting erythema, scaling, and pruritus
- PRO EXO Epi New applied topically to affected scalp regions
- Daily homecare: Minox Shampoo, Minox Scalp Serum, Azolei Shampoo, Azolei Scalp Serum
- Follow-up at 2 weeks; transplant proceeded on cleared scalp
Conclusion
A 2-week course of PRO EXO Epi New resolved active seborrhoeic dermatitis and restored a transplant-ready scalp environment, demonstrating the value of pre-operative scalp optimisation with targeted regenerative topicals.
Chronic Exercise-Associated Dandruff — PRO EXO Epi New
Before
After
Key Outcomes
| Measure | Baseline | Post-Treatment |
|---|---|---|
| Clinical Symptoms | Recurrent flaking post-exercise; prior treatments caused dryness | Marked reduction; no hair dryness |
| Scalp Condition | Adherent scales; follicular obstruction | Clearer scalp; follicles unobstructed |
| Clinical Finding | Chronic dandruff resistant to prior therapy | Scalp balance restored; hydration maintained |
Background
Exercise-associated dandruff reflects heightened scalp sensitivity and microbiome dysregulation driven by perspiration. Many conventional antidandruff formulations can compromise hair moisture and scalp barrier integrity with prolonged use. Exosome-based interventions address both the inflammatory and microbiome components without sacrificing scalp hydration.
Patient Profile
5-year history of recurrent exercise-triggered dandruff, with flaking occurring within one day of last wash. Previous treatments trialled but discontinued due to resultant hair dryness. No prior treatment provided durable relief.
Protocol
- Baseline scalp photography and assessment of flaking distribution
- PRO EXO Epi New applied topically as primary in-clinic intervention
- Daily homecare: Azolei Shampoo and Azolei Scalp Serum
- Clinical and subjective follow-up at 2 weeks
Conclusion
PRO EXO Epi New with Azolei homecare resolved chronic exercise-associated dandruff within 2 weeks without drying effects — highlighting the potential of exosome-based therapy to resolve microbiome-driven dandruff while preserving scalp barrier integrity.
Male AGA (Vertex) — PRO EXO Gen Men & Super Recovery via Plasma Energy TDDS
Before
After
Key Outcomes
| Measure | Baseline | Post-Treatment |
|---|---|---|
| Norwood–Hamilton | Stage III Vertex | Trending Stage II–III |
| Savin Density | Grade 3–4 | Grade 2–3 |
| Density Improvement | 10–15% reduction vs surrounding | 40–50% increase vs baseline |
Background
Vertex hair loss presents unique treatment challenges due to reduced scalp vascularity relative to the frontal zone. Plasma Energy TDDS offers a needle-free mechanism for driving regenerative actives deeper into the follicular unit — an emerging delivery modality for exosome-based biologics and a well-tolerated option for patients who decline microneedling.
Patient Profile
Male patient with clinically significant crown and vertex thinning at Norwood–Hamilton Stage III Vertex, with clear scalp visibility and estimated 10–15% density reduction compared to surrounding hair-bearing areas. Commenced on weekly Plasma Energy TDDS protocol.
Protocol
- Baseline photography and Savin density grading at crown
- PRO EXO Gen Men and Super Recovery vials prepared per protocol
- Plasma Energy TDDS device applied to vertex to create transdermal channels
- PRO EXO Gen Men and Super Recovery applied and absorbed via Plasma Energy device
- Weekly sessions — 8 total
Conclusion
Eight weekly sessions via Plasma Energy TDDS achieved an estimated 40–50% improvement in crown density, confirming the efficacy of non-invasive biologic delivery for vertex hair loss and supporting Plasma Energy TDDS as a clinically meaningful alternative to microneedling-assisted protocols.
Female AGA (Central Parting) — PRO EXO Gen Fem & Super Recovery via Plasma Energy TDDS
Before
After
Key Outcomes
| Measure | Baseline | Post-Treatment |
|---|---|---|
| Ludwig Scale | Stage I–II | Stage I |
| Savin Density | Grade 4–5 | Grade 3 |
| Density Improvement | Visible scalp; widened part | 40–50% improvement; part narrowed |
Background
Female AGA affects approximately 40% of women by age 50, causing visible midline parting widening with significant psychosocial impact. Exosome-based regenerative therapies offer a promising and well-tolerated option for female patients who prefer not to use hormonal or pharmacological interventions.
Patient Profile
Female patient with diffuse midline thinning consistent with Ludwig Stage I–II. Baseline showed widened central part with scalp show-through and reduced hair calibre. Daily Minox homecare prescribed throughout.
Protocol
- Baseline photography and Ludwig scale classification
- PRO EXO Gen Fem and Super Recovery vials prepared
- Plasma Energy TDDS applied along central parting
- PRO EXO Gen Fem and Super Recovery applied and absorbed via Plasma Energy
- Daily homecare: Minox Shampoo and Minox Scalp Serum throughout
- Weekly sessions — 8 total
Conclusion
Eight weekly sessions produced a clinically meaningful shift from Ludwig Stage I–II to Stage I, with 40–50% improvement in scalp show-through — a significant cosmetic and clinical outcome for this patient group.
Alopecia Areata (Patchy Type) — PRO EXO Gen Fem & Super Recovery via Plasma Energy TDDS
Before
After
Key Outcomes
| Measure | Baseline | Post-Treatment |
|---|---|---|
| AA Severity | 2.5–3 cm bald patch, left temporal | Reduced bald area; follicles repopulated |
| Savin Density (Crown) | Grade 4–5 | Grade 3 |
| Clinical Finding | Smooth bald patch; preserved follicular openings | Visible regrowth; no adverse effects |
Background
Alopecia areata is an autoimmune, non-scarring hair loss condition affecting ~2% of the global population. Standard treatments include intralesional corticosteroids and topical immunotherapy, with variable acceptability. Regenerative biologics with immunomodulatory properties offer a well-tolerated alternative, particularly for localised patchy disease.
Patient Profile
Female patient with well-demarcated ~2.5–3 cm alopecic patch at left temporal scalp, consistent with patchy-type alopecia areata. Concurrent crown parting widening at Savin Grade 4–5. Assessed as suitable for non-invasive regenerative biologic therapy.
Protocol
- Baseline photography and patch dimension assessment; Savin grading of crown
- PRO EXO Gen Fem and Super Recovery vials prepared
- Plasma Energy TDDS applied over alopecic patch and crown parting
- PRO EXO Gen Fem and Super Recovery applied and absorbed via Plasma Energy
- Biweekly sessions — 3 total
Conclusion
Three biweekly sessions resulted in visible hair regrowth within the alopecic patch and improved midline density, supporting the potential of exosome-based therapy as a well-tolerated, non-pharmacological adjunct for patchy alopecia areata.
Male AGA (Vertex) — Minox Root Reactivator Homecare Regimen
Before
After
Key Outcomes
| Measure | Baseline | Post-Treatment |
|---|---|---|
| Norwood–Hamilton | Stage III Vertex | Stage II–III |
| Savin Density | Grade 4 | Grade 3 |
| Density Improvement | Sparse crown coverage | 30–35% improvement; thicker shafts |
Background
Structured medical-grade homecare provides a scalable approach to maintaining follicular health, particularly for patients at earlier stages of hair loss or seeking accessible adjunctive therapy between clinic sessions. Ossome® Minox Root Reactivator Shampoo and Scalp Reactivating Serum leverage targeted reactivation technology to support follicular function as part of a daily routine.
Patient Profile
Male patient with vertex thinning at Norwood–Hamilton Stage III Vertex with clear scalp exposure at the crown. Assessed as an appropriate candidate for a structured homecare protocol as the primary intervention.
Protocol
- Baseline photography and Savin density grading of crown and vertex
- Minox Root Reactivator Shampoo prescribed for once-daily use
- Scalp Reactivating Serum prescribed for twice-daily application (morning and night)
- Compliance and technique reviewed at follow-up; clinical assessment at 1 month
Conclusion
One month of consistent daily Minox homecare produced approximately 30–35% improvement in crown coverage, highlighting the clinical value of structured, medically supervised homecare as an accessible and effective first-line approach for early-stage vertex hair loss.
Age-Related Scalp Atrophy with Female Pattern Thinning — PRO EXO Collagen Shield via Plasma Energy TDDS
Before
After
Key Outcomes
| Measure | Baseline | Post-Treatment |
|---|---|---|
| Ludwig Scale | Stage I–II | Stage I |
| Scalp Condition | Dry, wrinkled, low follicular grip | Hydrated, firmer, smoother |
| Clinical Finding | Scalp atrophy; weak anchorage | Restored elasticity; early thickening |
Background
Scalp ageing is characterised by progressive loss of collagen density, declining microcirculation, and thinning of the dermal layer. These changes diminish follicular anchorage strength and impair the follicular microenvironment. Regenerative collagen-stimulating therapies targeting the scalp dermis represent a novel approach to addressing the structural root cause of age-related follicular decline.
Patient Profile
Mature female patient with age-related scalp atrophy: visible scalp dryness, loss of elasticity, and reduced follicular anchorage strength. Concurrent female pattern thinning at Ludwig Stage I–II. Scalp surface dry, wrinkled, and lacking suppleness.
Protocol
- Baseline photography, Ludwig classification, and tactile scalp assessment
- PRO EXO Collagen Shield vials prepared per protocol
- Plasma Energy TDDS applied to central parting and crown
- PRO EXO Collagen Shield applied and absorbed via Plasma Energy device
- Twice-weekly sessions — 2-month total course
Conclusion
Two months of PRO EXO Collagen Shield via Plasma Energy TDDS improved scalp quality and hair density, with measurable gains in hydration, elasticity, anchorage strength, and Ludwig classification — highlighting Collagen Shield as a targeted regenerative anti-ageing scalp therapy.
Male AGA (Vertex) — PRO EXO Gen Men via Plasma Energy TDDS + Minox Homecare
Before
After
Key Outcomes
| Measure | Baseline | Post-Treatment |
|---|---|---|
| Norwood–Hamilton | Stage III Vertex | Stage II–III |
| Savin Density | Grade 4 | Grade 3 |
| Density Improvement | Noticeable scalp exposure; thin shafts | 35–40% improvement in crown density |
Background
The combination of in-clinic regenerative biologic therapy with structured daily homecare represents a comprehensive treatment model for AGA that targets hair loss from both a clinical and maintenance perspective. This modular approach — combining professional treatment with patient-managed homecare — reflects best practice in regenerative scalp care.
Patient Profile
Male patient with vertex hair loss at Norwood–Hamilton Stage III Vertex, distinct crown thinning and scalp exposure. Commenced on combined weekly PRO EXO Gen Men sessions via Plasma Energy TDDS and daily Minox homecare.
Protocol
- Baseline photography and Savin density grading of crown and vertex
- PRO EXO Gen Men vial prepared per protocol
- Plasma Energy TDDS applied to vertex scalp
- PRO EXO Gen Men applied and absorbed via Plasma Energy
- Daily homecare: Minox Shampoo (once daily) and Minox Scalp Serum (once daily)
- Weekly sessions — 4 total over 1 month
Conclusion
A combined 4-session in-clinic protocol with daily Minox homecare produced 35–40% improvement in crown density within 1 month, reinforcing the effectiveness of Ossome's modular regenerative system combining targeted professional treatment with structured home maintenance.
Male AGA with Scalp Folliculitis — PRO EXO Gen Men & Sebo Cure via Microneedling
Before
After
Key Outcomes
| Measure | Baseline | Post-Treatment |
|---|---|---|
| Norwood–Hamilton | Stage III Vertex + active folliculitis | Stage II–III; inflammation resolved |
| Savin Density | Grade 4–5 | Grade 3 |
| Clinical Finding | Oily scalp, papules, pruritus, poor anchorage | Scalp balanced; stronger anchorage; thicker shafts |
Background
Scalp folliculitis co-occurring with AGA creates a compounded challenge: the micro-inflammatory environment accelerates follicular miniaturisation, while standard AGA treatments may exacerbate follicular sensitivity. Effective management requires a dual-action protocol that simultaneously addresses androgenetic and inflammatory components.
Patient Profile
32-year-old male, 3-year history of progressive vertex thinning with recurrent papular scalp eruptions consistent with folliculitis. Norwood–Hamilton Stage III Vertex; Savin Grade 4–5. Oily scalp with active papules, pruritus, and poor follicular anchorage.
Protocol
- Baseline photography, Norwood–Hamilton staging, Savin grading, and folliculitis severity documentation
- PRO EXO Gen Men and PRO EXO Sebo Cure vials prepared
- Microneedling applied to vertex scalp for transdermal channel creation
- PRO EXO Gen Men (regenerative) and Sebo Cure (microbiome balancer) applied and massaged until absorbed
- Daily homecare: Minox Shampoo, Minox Scalp Serum, Azolei Shampoo, Azolei Scalp Serum
- Biweekly sessions — 7 total over 3.5 months
Conclusion
The dual-action PRO EXO Gen Men and Sebo Cure protocol resolved active folliculitis and improved vertex density by approximately 40%, demonstrating the effectiveness of targeted multi-component biologic therapy for the clinically complex presentation of concurrent AGA and scalp folliculitis.